Calcineurin Activity in Tacrolimus-Treated Renal Transplant Patients Early After and 5 Years After Transplantation

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

Claude B. Klee, Barbara E. Bierer, Steven J. Burakoff · Proceedings of the National Academy of Sciences · 1992 · 820 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Two distinct action mechanisms of immunophilin–ligand complexes for the blockade of T‐cell activation

Satoshi Matsuda, Futoshi Shibasaki, Kenji Takehana et al. · EMBO Reports · 2000 · 157 citations · Full text

Life Sciences, Immunology, Molecular Biology +14

Pharmacodynamic Approach to Immunosuppressive Therapies Using Calcineurin Inhibitors and Mycophenolate Mofetil

Olga Millán, Merçè Brunet, Josep M. Campistol et al. · Clinical Chemistry · 2003 · 53 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis

Ulrike Krummrei, Étienne-Émile Baulieu, Béatrice Chambraud · Proceedings of the National Academy of Sciences · 2003 · 41 citations

Life Sciences, Immunology, Pharmacology +15

Evaluation of the new EMIT enzyme immunoassay for the determination of whole-blood tacrolimus concentrations in kidney, heart, and liver transplant recipients

C. J. Hesse, Carla C. Baan, Aggie H.M.M. Balk et al. · Transplantation Proceedings · 2002 · 32 citations

Medicine, Nephrology, Pharmacology +16