Asymmetric S_N1 α‐Alkylation of Cyclic Ketones Catalyzed by Functionalized Chiral Ionic Liquid (FCIL) Organocatalysts

Abstract

Ionic liquid works better: The first intermolecular asymmetric α-alkylation of cyclic ketones was realized by using functionalized chiral ionic liquids as catalysts. The reaction proceeded with good to excellent yields and high ee. Highly stereoselective desymmetrization of 4-substituted cyclohexanones with >99:1 d.r. and up to 87 % ee were achieved by using this protocol.