Publication | Closed Access
A Fluorescence “Turn-On” Ensemble for Acetylcholinesterase Activity Assay and Inhibitor Screening
109
Citations
20
References
2009
Year
Medicinal ChemistryBiochemistryMedicineNatural SciencesBioanalysisNew FluorescenceAcetylcholinesterase Activity AssayAche AssayAnalytical ChemistrySingle-molecule DetectionAtomic Fluorescence SpectroscopyClinical ChemistryInhibitor ScreeningChemical ProbePharmacologyCompound 1Drug DiscoveryDrug Analysis
By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening.
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