Concepedia

SAR studies of 3,14,19-derivatives of andrographolide on anti-proliferative activity to cancer cells and toxicity to zebrafish: an in vitro and in vivo study

Yuran Peng, Jingjing Li, Yicheng Sun, Judy Yuet‐Wa Chan, Dekuan Sheng, Kun Wang, Ping Wei, Pingkai Ouyang, Decai Wang, Simon Ming‐Yuen Lee,

RSC Advances · 2015 · 27 citations · 19 references

DOI

Concepts

Abstract

Andrographolide is bestowed with an interesting pharmacophore and has attracted numerous studies on the design and synthesis of andrographolide derivatives.

References

19

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Jason Rihel, David A. Prober, Anthony C. Arvanites et al. · Science · 2010 · 794 citations · Full text

, , +17

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

David Kokel, Jennifer Bryan, Christian Laggner et al. · Nature Chemical Biology · 2010 · 540 citations · Full text

, , +12

Anticancer and immunostimulatory compounds from Andrographis paniculata

R. Ajaya Kumar, K Sridevi, Nitin Kumar et al. · Journal of Ethnopharmacology · 2004 · 528 citations

, , +14

Semisynthesis and in vitro anticancer activities of andrographolide analogues

Srinivasa Rao Jada, Genevieve Suseno Subur, Charlie Matthews et al. · Phytochemistry · 2007 · 138 citations

, , +13

Dehydroandrographolide Succinic Acid Monoester as an Inhibitor against the Human Immunodeficiency Virus

R. Shihman Chang, Liang Ding, C. Gai-Qing et al. · Experimental Biology and Medicine · 1991 · 113 citations

, , +10