Synthesis of 3,5,7‐Trioxapentacyclo[7.2.1.0^2,8.0^4,11.0^6,10]dodecane. A Novel Diacetal Trioxa‐Cage

Abstract

Abstract 3,5,7‐Trioxapentacyclo[7.2.1.0 2,8 .0 4,11 .0 6,10 ]dodecane, the parent compound of novel diacetal trioxa‐cages, was synthesized from maleic anhydride cyclopentadiene adduct 1 by a four‐step sequence. Attempts for the synthesis of monoaza dioxa‐cage 12 failed. Ozonolysis of compound 9 in CH 2 Cl 2 ‐EtOH(1:1) at −78°C followed by reduction with Me 2 S gave 13 in 65% yield.