New Cytotoxic Cucurbitacins from the Pericarps of<i>Trichosanthes Tricuspidata</i>Fruits

Abstract

An extract of the fruits of Trichosanthes tricuspidata collected in North Vietnam was found cytotoxic in KB cells. A bioassay-guided fractionation led to the isolation of a series of cucurbitacins of which two are new: tricuspidatin and 2-O-glucocucurbitacin J. Their isolation and structure determination are described.