Agricultural and Biological Chemistry · 1969 · 20 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryEicosanoid BiosynthesisHeterocycle SynthesisHeterocyclic ChemistryMacrocycle SynthesisSteroid StructureGrignard Reagent SynthesisMedicinal Chemistry ApplicationsProstaglandin Analogues
An alternative route to dl-prostaglandin-B1 using the Grignard reaction of 2-(6'-tert-butyloxycarbonylhexyl)-3-methoxy-2-cyclopenten-1-one (XII) with 3-tetrahydropyranyloxy-1-octyne was developed. An easy synthesis of dihydrojasmone was also described.