ENHANCED INHIBITION OF HIV-1 REPLICATION IN MACROPHAGES BY ANTISENSE OLIGONUCLEOTIDES, RIBOZYMES AND ACYCLIC NUCLEOSIDE PHOSPHONATE ANALOGS DELIVERED IN pH-SENSITIVE LIPOSOMES

Abstract

An antisense oligodeoxynucleotide against the human immunodeficiency virus type 1 (HIV-1) Rev response element, a ribozyme complementary to the HIV-1 5'-LTR, and the reverse transcriptase inhibitors 9-(2-phosphonylmethoxyethyl) adenine (PMEA) and (R)-9-(2-phosphonylmethoxypropyl)-adenine (PMPA) inhibited virus replication in monocyte-derived macrophages more effectively when delivered in pH-sensitive liposomes compared to the free drugs.