Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement

Abstract

Core–multishell nanoparticles: Near-IR-resonant rhodamine-encapsulated poly(lactic-co-glycolic acid) (PLGA)–Mn/Au half-shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic resonance imaging. Upon NIR irradiation, the release rate of rhodamine from the PLGA NPs is about twice as great as that without NIR irradiation, indicating photothermally controlled drug delivery possibilities.