Antimicrobial Aromatic Polyketides from Gorgonian‐Associated Fungus, <i>Penicillium commune </i>518

Abstract

Abstract Seven new aromatic polyketides, communols A–G ( 1 – 7 ), were isolated and identified from the fermentation broth of Penicillium commune 518, a marine‐derived fungus associated with the Gorgonian, Muricella abnormalis . The new structures of 1 – 7 were determined by spectroscopic analysis and X‐ray single crystal diffraction. Among them, communol D ( 4 ) was the first example of a naturally occurring aromatic polyketide with a sulfoxide group from marine fungi. Compounds 1 , 6 , and 7 all showed moderate antimicrobial activities against Escherichia coli and Enterobacter aerogenes with MIC values of 4.1/16.4, 6.4/25.8, and 23.8/23.8 µmol·L −1 , respectively.