K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer

Genetic Alterations during Colorectal-Tumor Development

Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton et al. · New England Journal of Medicine · 1988 · 6.8K citations

Medicine, Genetics, Oncology +14

Allele-Specific Chromosome 3p Deletions Occur at an Early Stage in the Pathogenesis of Lung Carcinoma

Jaclyn Y. Hung · JAMA · 1995 · 341 citations

Life Sciences, Genetics, Molecular Genetics +13

Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines

Tetsuya Mitsudomi, Jean Viallet, James L. Mulshine et al. · Lung Cancer · 1992 · 298 citations

Medicine, Genetics, Oncology +16

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

V. Sundaresan, Peter Ganly, P S Hasleton et al. · Lung Cancer · 1993 · 259 citations

Medicine, Oncology, Pathology +12

K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.

William H. Westra, Inge O. Baas, R.H. Hruban et al. · PubMed · 1996 · 224 citations

Medicine, Genetics, Oncology +17