Neuroreport · 2004 · 26 citations · 15 references
MedicineEndocrinologyPhysiologyExercise PhysiologyMetabolic RegulationNeuroendocrinologyAdipose TissueHypothalamic-pituitary AxisInsulin ResistanceMetabolic Adaptation To ExerciseMetabolic Responses To ExerciseRodent EndocrinologyArcuate NucleusEndocrine Adaptation To ExerciseExercise-induced Insulin SensitivityHormonal Regulation Of Exercise MetabolismInsulin Sensitivity AdaptationInsulin Sensitivity After ExerciseLeptin ResistanceLeptin Signaling
The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.
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Role of leptin in the neuroendocrine response to fasting
Rexford S. Ahima, Daniel Prabakaran, Christos S. Mantzoros et al. · Nature · 1996 · 3.1K citations