Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

Theodore J. Iwashyna, E. Wesley Ely, Dylan M. Smith et al. · JAMA · 2010 · 2.6K citations

Medicine, Neurology, Psychiatry +16

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi et al. · Nature Medicine · 2007 · 2.5K citations

Life Sciences, Biochemistry, Pharmacology +13

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

Rajesh K. Thimmulappa · Journal of Clinical Investigation · 2006 · 1K citations · Full text

Veterinary Medicine, Immunology, Pathobiology +17

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Andy Y. Shih, Delinda A. Johnson, Gloria Wong et al. · Journal of Neuroscience · 2003 · 782 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury

Kentaro Hayashida, Motoaki Sano, Ikuroh Ohsawa et al. · Biochemical and Biophysical Research Communications · 2008 · 475 citations

Medicine, Cardiology, Physiology +6