Proceedings of the National Academy of Sciences · 1980 · 555 citations · 41 references
Life SciencesBiologyMolecular BiologyGenome OrganizationNucleic Acid BiochemistryRna ProcessingIntron StructureRna SplicingSmall Nuclear Rna BiologySmall Nuclear Rna ProcessingSmall Nuclear RnasSplice Site RecognitionU1 Small Nuclear Rna
The most abundant of the stable small nuclear RNAs of eukaryotic cells, U-1 small nuclear RNA, is exactly complementary to the consensus sequences at RNA splice sites. We propose that this RNA is the recognition component of the nuclear RNA splicing enzyme and forms base pairs with both ends of an intron so as to align them for cutting and splicing.
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