Chemical Communications · 1997 · 18 citations · 5 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryCatalyst DesignCatalyst PreparationCatalyst SynthesisChemoenzymatic SynthesisHeterocycle SynthesisOrganic SynthesisChemoenzymatic Asymmetric SynthesisHydrogenationHydrogenation CatalysisHydrogenation ReactionsLigand DesignMolecular Hydrogenation ProcessesStereoselectivityStereoselectivity Control
The hydrogenation of alkenes 7a–g using a chiral rhodium catalyst 6 (based on a bicyclo[3.2.0]heptane framework) takes place to give the phenylalanine derivatives 8a–g with remarkably high stereoselectivity (59–92% ee).
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