Rhodium‐Catalyzed Highly Enantioselective Addition of Arylboronic Acids to 2‐Nitrostyrenes by <i>tert</i>‐Butanesulfinylphosphine Ligand

Abstract

Particularly picky ligands! An efficient (S/C, substrate/catalyst, up to 500) Rh-catalyzed enantioselective addition of arylboronic acids to 2-nitrostyrenes under mild conditions was developed, which gave excellent yields (up to 99 %) and enantioselectivities (up to 98 % ee) by using tert-butanesulfinylphosphine as a ligand (see scheme). Based on this method, (R)-cherylline was synthesized in 70 % overall yield. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.