Genetic Testing in Medullary Thyroid Carcinoma Syndromes: Mutation Types and Clinical Significance

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

Robert M.W. Hofstra, Rudy M. Landsvater, Isabella Ceccherini et al. · Nature · 1994 · 1.2K citations

Medicine, Genetics, Oncology +16

Activation of <i>RET</i> as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

Massimo Santoro, Francesca Carlomagno, Alfredo Romano et al. · Science · 1995 · 838 citations

Medicine, Genetics, Molecular Genetics +17

Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

Lois M. Mulligan, Charis Eng, Catherine S. Healey et al. · Nature Genetics · 1994 · 651 citations

Life Sciences, Genetics, Molecular Genetics +16

Single missense mutation in the tyrosine kinasecatalytic domain of the RET protooncogene is associated with multiple endocrineneoplasia type 2B.

Katrin M. Carlson, Shuo‐Xing Dou, N J Scavarda et al. · Proceedings of the National Academy of Sciences · 1994 · 598 citations · Full text

Medicine, Genetics, Oncology +17

Predictive DNA Testing and Prophylactic Thyroidectomy in Patients at Risk for Multiple Endocrine Neoplasia Type 2A

Samuel A. Wells, Doina David, Koji Toshima et al. · Annals of Surgery · 1994 · 447 citations

Life Sciences, Endocrinology, Genetics +17