The relationship between peptide structure and transport across epithelial cell monolayers

The Fluid Mosaic Model of the Structure of Cell Membranes

Sherwin J. Singer, Garth L. Nicolson · Science · 1972 · 9K citations

Natural Sciences, Biology, Biophysics +17

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

Ismael J. Hidalgo, Thomas J. Raub, Ronald T. Borchardt · Gastroenterology · 1989 · 2.2K citations

Life Sciences, Cell Biology, Oncology +14

Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal Mucosa

Allen R. Hilgers, Robert A. Conradi, Philip S. Burton · Pharmaceutical Research · 1990 · 582 citations

Pharmacy, Pharmaceutics, Pharmacology +15

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

Rodney C. Young, Robert Cameron Mitchell, Thomas H. Brown et al. · Journal of Medicinal Chemistry · 1988 · 522 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

The nature of the hydrophobic binding of small peptides at the bilayer interface: implications for the insertion of transbilayer helices

Russell E. Jacobs, Stephen H. White · Biochemistry · 1989 · 436 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16