Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists

Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

Robert S. Ames, Henry M. Sarau, Johathan K. Chambers et al. · Nature · 1999 · 789 citations

Medicine, Pharmacology, Molecular Pharmacology +5

Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord

Yolaine Coulouarn, Isabelle Lihrmann, Sylvie Jégou et al. · Proceedings of the National Academy of Sciences · 1998 · 395 citations

Life Sciences, Molecular Biology, Neuroscience +8

U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.

David I. Yule, John A. Williams · Journal of Biological Chemistry · 1992 · 300 citations · Full text

Medicine, Biochemistry, Pharmacology +16

Human Urotensin II–Induced Contraction and Arterial Smooth Muscle Cell Proliferation Are Mediated by RhoA and Rho-Kinase

Vincent Sauzeau, Erik Le Mellionnec, Jacques Bertoglio et al. · Circulation Research · 2001 · 259 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Orphan‐receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin‐1

Janet J. Maguire, Rhoda E. Kuc, Anthony P. Davenport · British Journal of Pharmacology · 2000 · 246 citations · Full text

Life Sciences, Neuroscience, Pharmacology +16