The effects of six antipsychotic agents on QTc—An attempt to mimic clinical trial through simulation including variability in the population

Timing of New Black Box Warnings and Withdrawals for Prescription Medications

Karen E. Lasser · JAMA · 2002 · 1K citations

Pharmacy, Pharmacology, Clinical Pharmacology +16

Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval

Marek Malík · Heart · 2002 · 441 citations · Full text

Life Sciences, Cardiology, Physiology +13

ICH E14: A New Regulatory Guidance on the Clinical Evaluation of QT/QTc Internal Prolongation and Proarrhythmic Potential for Non-antiarrhythmic Drugs

Philip T. Sager, T Nebout, Börje Darpö · Drug Information Journal · 2005 · 386 citations

Medicine, Cardiology, Pharmacology +17

A Randomized Evaluation of the Effects of Six Antipsychotic Agents on QTc, In the Absence and Presence of Metabolic Inhibition

Edmund P. Harrigan, Jeffrey Miceli, Richard Anziano et al. · Journal of Clinical Psychopharmacology · 2004 · 358 citations

Medicine, Pharmacokinetics, Pharmacology +14

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

James Kramer, Carlos A. Obejero‐Paz, Glenn J. Myatt et al. · Scientific Reports · 2013 · 352 citations · Full text

Medicine, Cardiology, Pharmacology +17