Photoactivated DNA cleavage via charge transfer promoted N2 release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

Abstract

Visible wavelength ligand-to-metal (LMCT) activated N2 release from tris(3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III) produces localized ligand radical intermediates capable of cleaving DNA and represents a new chemical approach to photonuclease design for biological applications.