NMDA Receptors on Non-Dopaminergic Neurons in the VTA Support Cocaine Sensitization

Abstract

These results eliminate the possibility of NMDAR mediated neuroplasticity in the different DA neuronal subpopulations in our NR1(DATCre) mouse model and therefore suggest that NMDARs on non-DA neurons within the VTA must play a major role in cocaine-related addictive behavior.