The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

A. Mahgoub, L. G. Dring, Jeffrey R. Idle et al. · The Lancet · 1977 · 1.2K citations

Pharmacy, Biochemistry, Pharmacology +6

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

Frank J. Gonzalez, Radek C. Skodat, Shioko Kimura et al. · Nature · 1988 · 718 citations

Life Sciences, Genetics, Molecular Genetics +12

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

Kōichi Nakamura, Fumio Goto, Wayne A. Ray et al. · Clinical Pharmacology & Therapeutics · 1985 · 457 citations

Pharmacy, Pharmacology, Toxicology +14

Oxidation of quinidine by human liver cytochrome P-450.

F. Peter Guengerich, Dieter Müller‐Enoch, Ian A. Blair · Molecular Pharmacology · 1986 · 306 citations

Medicine, Biochemistry, Pharmacology +16

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

S V Otton, T. Inaba, W. Kalow · Life Sciences · 1984 · 187 citations

Medicine, Medicinal Chemistry, Pharmacology +13