Publication | Closed Access
The Influence of a β-Electron Withdrawing Substituent in Aldol Reactions of Methylketone Boron Enolates
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Citations
32
References
2007
Year
Asymmetric CatalysisCross-coupling ReactionEngineeringBeta-trichloromethyl MethylketonesBiochemistryβ-Electron Withdrawing SubstituentNatural SciencesBoron-mediated Aldol ReactionsOrganic ChemistryAldol ReactionsStereoselective SynthesisChemistryBeta-alkoxy Protecting GroupChemical KineticsEnantioselective SynthesisBiomolecular EngineeringMethylketone Boron Enolates
We wish to describe here that good levels of substrate-based, 1,5-syn-stereocontrol could be achieved in the boron-mediated aldol reactions of beta-trichloromethyl methylketones with achiral aldehydes, independent of the nature of the beta-alkoxy protecting group.
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