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Semisyntheses, X-Ray Crystal Structures and Tubulin-Binding Properties of 7-Oxodeacetamidocolchicine and 7-Oxodeacetamidoisocolchicine
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1992
Year
X-ray CrystallographyBioorganic ChemistryMolecular BiologyOrganic ChemistryPeptide ScienceChemical BiologyPharmaceutical ChemistryMedicinal ChemistryProtein X-ray CrystallographyStructure ElucidationProtein ChemistryBiochemistryTitle KetonesX-ray Crystal StructuresPharmacologyMolecular ModelingCrystallographyNatural Product SynthesisStructural BiologyX-ray StructuresNatural SciencesPeptide SynthesisTubulin-binding PropertiesMedicine
Commercially available (–)-colchicine (1) has been converted, via deacetylcolchiceine (4), into a mixture of 7-oxodeacetamidocolchicine (2) and 7-oxodeacetamidoisocolchicine (3). The X-ray structures and tubulin-binding properties of these title ketones are described.