Concepedia

Vicinal diamination of 1,4-dihydropyridines

Rodolfo Lavilla, Rakesh Kumar, Oscar Coll, Carme Masdeu, Joan Bosch

Chemical Communications · 1998 · 18 citations · 11 references

DOI

Concepts

Abstract

Electrophilic interaction of iodine with N-alkyl-1,4-dihydropyridines 1 in the presence of secondary amines stereoselectively leads to the corresponding trans-2,3-diamino-1,2,3,4-tetrahydropyridines 2 in satisfactory yields (79–94%); the method allows the synthesis of piperidine, pyrrolidine, morpholine and piperazine derivatives.

References

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