PORCINE KIDNEY AND HEART TRANSPLANTATION IN BABOONS UNDERGOING A TOLERANCE INDUCTION REGIMEN AND ANTIBODY ADSORPTION1

Abstract

This conditioning regimen prevented hyperacute rejection but was ineffective in preventing the return of Ab, which was associated with the development of acute humoral rejection with features of coagulopathy. No baboon developed anti-pig Ab other than alphaGal Ab. Further modifications of the protocol directed toward suppression of production of Ab are required to successfully induce tolerance to pig organs in baboons.