Autocrine Regulation of Growth by Insulin-Like Growth Factor (IGF)-II Mediated by Type I IGF-Receptor in Wilms Tumor Cells

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

Thomas M. DeChiara, Argiris Efstratiadis, Elizabeth J. Robertsen · Nature · 1990 · 1.6K citations

Knockout Mouse, Metabolic Syndrome, Developmental Biology +8

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

Emily Rinderknecht, R Humbel · Journal of Biological Chemistry · 1978 · 1.5K citations · Full text

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

Manfred Gessler, Annemarie Poustka, Webster K. Cavenee et al. · Nature · 1990 · 1.3K citations

Chromatin, Genome Instability, Developmental Biology +14

Insulin-like growth factor I stimulates growth in hypophysectomized rats

Eugen J. Schoenle, Jürgen Zapf, R Humbel et al. · Nature · 1982 · 597 citations

Metabolic Syndrome, Growth Hormone, Insulin-like Growth Factor +7

Radioimmunological determination of insulinlike growth factors I and II in normal subjects and in patients with growth disorders and extrapancreatic tumor hypoglycemia.

J. Zapf, Henrik Walter, E. R. Froesch · Journal of Clinical Investigation · 1981 · 596 citations · Full text

Metabolic Syndrome, Growth Disorders, Growth Hormone +13