Biosynthesis of the Heat‐Shock Protein 90 Inhibitor Geldanamycin: New Insight into the Formation of the Benzoquinone Moiety

Abstract

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2006/z500441_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.