Concepedia

Biosynthesis of the Heat‐Shock Protein 90 Inhibitor Geldanamycin: New Insight into the Formation of the Benzoquinone Moiety

Dongho Lee, Kyeong Lee, Xing Fu Cai, Nguyễn Tiến Đạt, Shanthaveerappa K. Boovanahalli, Mijeoung Lee, Jin Chul Shin, Won-Cheol Kim, Jae Kap Jeong, Jong Suk Lee,

ChemBioChem · 2006 · 29 citations · 13 references

DOI

Concepts

Abstract

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

References

13

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

C. Erec Stebbins, Alicia A. Russo, Christine Schneider et al. · Cell · 1997 · 1.4K citations · Full text

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GELDANAMYCIN, A NEW ANTIBIOTIC

C. DeBoer, P. A. MEULMAN, Richard J. Wnuk et al. · The Journal of Antibiotics · 1970 · 467 citations · Full text

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Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives

Rodney C. Schnur, Michael L. Corman, Randall J. Gallaschun et al. · Journal of Medicinal Chemistry · 1995 · 199 citations

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Herbimycin, a new antibiotic produced by a strain of Streptomyces.

Satoshi Ōmura, YUZURU IWAI, Yōko Takahashi et al. · The Journal of Antibiotics · 1979 · 172 citations · Full text

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Cloning and characterization of a gene cluster for geldanamycin production in<i>Streptomyces hygroscopicus</i>NRRL 3602

Andreas Rascher, Zhihao Hu, N. Viswanathan et al. · FEMS Microbiology Letters · 2003 · 151 citations · Full text

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