Naturally occurring biflavonoid, ochanflavone, inhibits cyclo-oxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Aspirin-like Drugs, Prostaglandin Synthesis, Biochemistry +8

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

M. Kerry O’Banion, Virginia D. Winn, David A. Young · Proceedings of the National Academy of Sciences · 1992 · 830 citations · Full text

Prostaglandin Synthesis, Immunology, Cell Death +19

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

Jeanette A.M. Maier, Timothy Hla, T Maciag · Journal of Biological Chemistry · 1990 · 486 citations · Full text

Inflammation, Endothelial Cell Pathobiology, Immediate-early Gene +15

Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa

Brendan J.R. Whittle, G.A. Higgs, K.E. Eakins et al. · Nature · 1980 · 396 citations

Inflammation, Anti-inflammatory, Medicine +8

IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release.

Masao Yamaguchi, K Sayama, Koji Yano et al. · PubMed · 1999 · 247 citations

Mast Cell Disorder, Immune Regulation, Immunology +17