Concepedia

Mst1-FoxO Signaling Protects Naïve T Lymphocytes from Cellular Oxidative Stress in Mice

Juhyun Choi, Sangphil Oh, Dongjun Lee, Hyun Jung Oh, Jik Young Park, Sean Bong Lee, Dae‐Sik Lim

PLoS ONE · 2009 · 115 citations · 31 references

Open access

Abstract

These data support the hypothesis that tolerance to increased levels of intracellular ROS provided by the Mst1-FoxOs signaling pathway is crucial for the maintenance of naïve T cell homeostasis in the periphery.

References

31

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Jens Dhein, Henning Walczak, Caroline Bäumler et al. · Nature · 1995 · 1.6K citations

T-regulatory Cell, Apoptosis, Immunology +7

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

Kimberly S. Schluns, William C. Kieper, Stephen C. Jameson et al. · Nature Immunology · 2000 · 1.6K citations

Inflammation, Autoimmune Disease, Adaptive Immune System +8

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Geert J.P.L. Kops, Tobias B. Dansen, Paulien E. Polderman et al. · Nature · 2002 · 1.5K citations

Reductive Stress, Transcriptional Regulation, Systems Biology +8

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Lixin Zheng, Galen H. Fisher, Robert E. Miller et al. · Nature · 1995 · 1.1K citations

Inflammation, Tumour Necrosis Factor, T-regulatory Cell +13

The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis

Kieran F. Harvey, Cathie M. Pfleger, Iswar K. Hariharan · Cell · 2003 · 975 citations · Full text

Developmental Biology, Cell Division, Genetics +10