Concepedia

Round Window Application of D-Methionine, Sodium Thiosulfate, Brain-Derived Neurotrophic Factor, and Fibroblast Growth Factor-2 in Cisplatin-Induced Ototoxicity

Christoph Wimmer, K. Mees, Péter Stumpf, Ulrich Welsch, Oliver Reichel, M. Suckfüll

Otology & Neurotology · 2004 · 88 citations · 33 references

DOI

Abstract

Local application to the round window membrane can be used as an effective treatment in the prevention of cisplatin toxicity. Local application may avoid systemic side effects and reduce the antineoplastic effects of cisplatin.

References

33

Mechanism of Cisplatin Ototoxicity: Antioxidant System

Radhika Ravi, Satu M. Somani, Leonard P. Rybak · Pharmacology & Toxicology · 1995 · 321 citations

Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells.

Richard D. Kopke, Wei Liu, Ramin Gabaizadeh et al. · PubMed · 1997 · 271 citations

d-Methionine provides excellent protection from cisplatin ototoxicity in the rat

Kathleen C. M. Campbell, Leonard P. Rybak, Robert P. Meech et al. · Hearing Research · 1996 · 238 citations

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Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant

Su-Hua Sha, Jochen Schacht · Hearing Research · 2000 · 223 citations

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Cisplatin‐Induced Ototoxicity: The Effect of Pigmentation and Inhibitory Agents

Vanessa G. Schweitzer · The Laryngoscope · 1993 · 153 citations

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