Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood–brain barrier

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Alfred H. Schinkel, Johan W. Jonker · Advanced Drug Delivery Reviews · 2003 · 1.4K citations

Medicine, Biochemistry, Pharmacology +14

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Alfred H. Schinkel, Johan W. Jonker · Advanced Drug Delivery Reviews · 2012 · 1.2K citations

Medicine, Biochemistry, Pharmacology +14

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Alfred H. Schinkel, Ulrich Mayer, Els Wagenaar et al. · Proceedings of the National Academy of Sciences · 1997 · 941 citations

Medicine, Pharmacokinetics, Pharmacology +11

The multidrug resistance protein family

Piet Borst, Raymond Evers, Marcel Kool et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 1999 · 650 citations

Life Sciences, Molecular Biology, Pharmacology +12