Concepedia

PR39 Inhibits Apoptosis in Hypoxic Endothelial Cells

Jia‐Ping Wu, Cherie P. Parungo, Guifu Wu, Peter M. Kang, Roger J. Laham, Frank W. Sellke, Michael Simons, Jian Li

Circulation · 2004 · 57 citations · 24 references

DOI

Abstract

We provide the first direct evidence for PR39 as an antiapoptotic factor in endothelial cells during hypoxia. These data suggest that PR39 inhibits hypoxia-induced apoptosis and decreases caspase-3 activity in endothelial cells through an increase of IAP-2 expression.

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