Changes in intracellular prostaglandin content during activation of lymphocytes by phytohaemagglutinin

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Aspirin-like Drugs, Prostaglandin Synthesis, Biochemistry +8

Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell.

James S. Goodwin, Arthur D. Bankhurst, Ronald P. Messner · The Journal of Experimental Medicine · 1977 · 794 citations

Human T-cell Mitogenesis, Pha Cultures, Lymphocyte Development +18

Guanosine 3′:5′-Cyclic Monophosphate: A Possible Intracellular Mediator of Mitogenic Influences in Lymphocytes

John W. Hadden, Elba M. Hadden, Mari K. Haddox et al. · Proceedings of the National Academy of Sciences · 1972 · 380 citations · Full text

Immunology, Molecular Biology, Cell Proliferation +23

Cyclic adenosine 3′,5′-monophosphate in human lymphocytes. Alterations after phytohemagglutinin stimulation

Jay W. Smith, Alton L. Steiner, W. Marcus Newberry et al. · Journal of Clinical Investigation · 1971 · 310 citations · Full text

Phytohemagglutinin Stimulation, Immunology, Cyclic Amp Concentration +16

Role of prostaglandin endoperoxide PGG2 in inflammatory processes

F. A. Kuehl, John L. Humes, Robert W. Egan et al. · Nature · 1977 · 308 citations

Inflammation, Anti-inflammatory, Medicine +8