Auto-activation of the Apoptosis Protein Bax Increases Mitochondrial Membrane Permeability and Is Inhibited by Bcl-2

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Zoltán N. Oltval, Curt Milliman, Stanley J. Korsmeyer · Cell · 1993 · 6K citations

Bcl-2 Heterodimerizes, Cell Regulation, Apoptosis +6

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Honglin Li, Hong Zhu, Chi-jie Xu et al. · Cell · 1998 · 4.4K citations · Full text

Mitophagy, Signal Transduction, Mitochondrial Damage +12

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

Michael C. Wei, Wei‐Xing Zong, Emily H. Cheng et al. · Science · 2001 · 3.9K citations · Full text

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

Xu Luo, I. Imawati Budihardjo, Hua Zou et al. · Cell · 1998 · 3.6K citations · Full text

Mitophagy, Signal Transduction, Biochemistry +10

The Pathophysiology of Mitochondrial Cell Death

Douglas R. Green, Guido Kroemer · Science · 2004 · 3.3K citations

Mitophagy, Signal Transduction, Permeability Transition Pore +15