Anti-invasive Effect of an Anti-Matrix Metalloproteinase Agent in a Murine Brain Slice Model Using the Serial Monitoring of Green Fluorescent Protein-labeled Glioma Cells

Abstract

This model enabled unequivocal periodic tracking of individual invading tumor cells in normal brain. The significant suppression of glioma cell invasion by noncytotoxic concentrations of SI-27 indicates that anti-MMP treatment may represent an important future therapeutic strategy for malignant cerebral neoplasms.