Resolution of Optical Isomers by Thin‐Layer Chromatography: Enantiomeric Purity of Methyldopa. Dünnschichtchromatographische Enantiomerentrennung: Enantiomere Reinheit von Methyldopa

Abstract

Abstract Just 20 % of chiral synthetic drugs are used as pure stereoisomers 1) , although it is known from numerous examples that optical isomers may have quite different biological effects 2) . Therefore the enantiomeric purity is an important probe for monitoring the quality of drugs. The availability of reliable analytical techniques for the correct determination of enantiomeric compositions is therefore becoming increasingly important. Such a method should allow us to deal successfully with the determination of small enantiomeric impurities.