COX-1, COX-2 and the topical effect in NSAID-induced enteropathy

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

Dean A. Kujubu, Bradley S. Fletcher, Brian Varnum et al. · Journal of Biological Chemistry · 1991 · 1.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Wei Xie, Jeffrey G. Chipman, Donald Robertson et al. · Proceedings of the National Academy of Sciences · 1991 · 1.7K citations

Life Sciences, Biochemistry, Molecular Biology +16

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full <i>in vitro</i> analysis

Timothy D. Warner, Francesco Giuliano, Ivana Vojnovic et al. · Proceedings of the National Academy of Sciences · 1999 · 1.5K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +12

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration

Robert Langenbach, Scott G. Morham, Howard F. Tiano et al. · Cell · 1995 · 1.1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +16