Concepedia

KIT oncoprotein interactions in gastrointestinal stromal tumors: therapeutic relevance

M-j Zhu, W-B Ou, Christopher D.�M. Fletcher, P S Cohen, George D. Demetri, Jonathan A. Fletcher

Oncogene · 2007 · 51 citations · 20 references

DOI

Concepts

References

20

Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors

Seiichi Hirota, Koji Isozaki, Y Moriyama et al. · Science · 1998 · 4.5K citations

, , +17

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

George D. Demetri, Margaret von Mehren, Charles D. Blanke et al. · New England Journal of Medicine · 2002 · 4.4K citations · Full text

, , +14

<i>PDGFRA</i> Activating Mutations in Gastrointestinal Stromal Tumors

Michael C. Heinrich, Christopher L. Corless, Anette Duensing et al. · Science · 2003 · 2.3K citations

, , +17

Gefitinib-Sensitizing <i>EGFR</i> Mutations in Lung Cancer Activate Anti-Apoptotic Pathways

Raffaella Sordella, Daphne W. Bell, Daniel A. Haber et al. · Science · 2004 · 1.6K citations

, , +17

KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.

Brian P. Rubin, Samuel Singer, C. Tsao et al. · PubMed · 2001 · 969 citations

, , +17