Molecular Recognition of Watson–Crick‐Like Purine–Purine Base Pairs

Abstract

Selection of a larger pair: Nucleic acid duplexes with non-Watson–Crick base pairs are of interest to fields that span structural biology, supramolecular chemistry, origin of life, and synthetic biology. Here we demonstrate that intercalating molecules can exhibit selective binding of duplexes with purine–purine base pairs over duplexes with Watson–Crick base pairs, and vice versa. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.