Somatic Mutation in Individual Liver Cysts Supports a Two-Hit Model of Cystogenesis in Autosomal Dominant Polycystic Kidney Disease

<b> <i>PKD2</i> </b> , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein

Toshio Mochizuki, Guanqing Wu, Tomohito Hayashi et al. · Science · 1996 · 1.4K citations

Medicine, Genetics, Molecular Genetics +17

Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies

Shirley Kwok, D.E. Kellogg, Nancy McKinney et al. · Nucleic Acids Research · 1990 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +11

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16

The European Polycystic Kidney Dise · Cell · 1994 · 902 citations · Full text

Medicine, Genetics, Molecular Genetics +9

PKD1 interacts with PKD2 through a probable coiled-coil domain

Qian Feng, F. Joseph Germino, Yiqiang Cai et al. · Nature Genetics · 1997 · 661 citations

Life Sciences, Biochemistry, Molecular Biology +8

The Molecular Basis of Focal Cyst Formation in Human Autosomal Dominant Polycystic Kidney Disease Type I

Feng Qian, Terry Watnick, Luiz F. Onuchic et al. · Cell · 1996 · 615 citations · Full text

Medicine, Genetics, Molecular Genetics +11