Relationship between adiponectin, leptin, <scp>IGF</scp>‐1 and total lipid peroxides plasma concentrations in patients with systemic sclerosis: possible role in disease development

Abstract

Adipose tissue may play a complex role in the development of dcSSc, affecting both the metabolic state of the organism, as well as free radical-induced connective tissue degradation. Although, leptin seems to exert a pro-oxidative effect and both adiponectin and IGF-1 appear to prevent free radical damage, confirmation of the above effects requires further research.