Altered human gut dendritic cell properties in ulcerative colitis are reversed by <i>Lactobacillus plantarum</i> extracellular encrypted peptide STp

Abstract

Colonic DCs display an abnormal immature phenotype in UC, which was partially restored following STp treatment. Bacteria-derived metabolites, like STp, seem to have a role in gut homeostasis that is missing in UC so they might lead a new era of probiotic products setting the basis for nondrug dietary therapy in inflammatory bowel disease.