Treatment of severe salicylate poisoning by forced alkaline diuresis.

Abstract

MEDIBCAJORNALthat, despite these differences, the biological response of the bronchial epithelium to both was similar if assessed by goblet cell increase.This similarity is in striking contrast to the difference in mitotic counts produced at higher doses.Daily exposure to smoke from more than 30 cigarettes produced so many mitoses that goblet cell counts as here described were not possible: there was no such excess from exposure to cigar smoke (Lamb, 1967; Passey and Blackmore, 1967).It has been shown, using sulphur dioxide as the irritant, that the alteration in goblet cell number does not parallel the severity of epithelial damage as measured by the mitotic count (Lamb and Reid, 1968).Loss of weight or failure to gain weight is usual in experimental animals exposed to tobacco smoke.This loss of weight is not usually attributable to the severity of pulmonary damage, and Elson and Passey (1963) produced evidence to suggest that the nicotine present in the tobacco smoke is the main cause of loss of weight.We would like to thank Miss R. Thomson for her technical