Human Intraocular Penetration of Sodium Oxacillin

Abstract

Patients about to undergo routine cataract extraction were given varying doses of sodium oxacillin by intramuscular injection. The injections were administered at regular intervals during the 24 hours prior to surgery. At time of operation aqueous and venous blood were obtained and subjected to bio-assay for oxacillin content. Bio-assay was by the plate inhibition method using<i>Sarcina lutea</i>as test organism. Oxacillin failed to penetrate the normal human blood aqueous barrier in detectable amounts in any patient.