Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Expression of a multidrug-resistance gene in human tumors and tissues.

Antonio Tito Fojo, Kazumitsu Ueda, Dennis J. Slamon et al. · Proceedings of the National Academy of Sciences · 1987 · 1.6K citations · Full text

Medicine, Oncology, Pharmacology +11

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

Victor A. Levin · Journal of Medicinal Chemistry · 1980 · 814 citations

Medicine, Pharmacology, Physiology +14

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Journal of Histochemistry & Cytochemistry · 1989 · 610 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14