Circulation · 2001 · 225 citations · 37 references
MedicinePharmacologyPharmacotherapyCardiovascular PharmacotherapyClinical PharmacologyPreventive CardiologyAtherosclerosis PharmacotherapyAtherosclerotic Cardiovascular Disease PreventionCardiovascular DiseaseCardiovascular Disease PreventionCardiovascular PharmacologyIschemic Heart DiseaseAntioxidant PharmacologyAtherosclerotic Cardiovascular Risk ReductionAtherosclerotic Disease PreventionCardiovascular Disease MortalityCarotid Artery UltrasonographyCarotid Artery UltrasoundOxidative Stress In Cardiovascular DiseaseOxidative Stress Injury
Outcomes Prevention Eval- uation (HOPE) study, 1,2 as well as the Study to Evaluate Carotid Ultrasound Changes in Patients Treated With Ramipril and Vitamin E (SECURE), 3 demonstrated that treatment with an ACE inhibitor but not vitamin E had beneficial effects on the prognosis and progression of atherosclerosis.In these studies, long-term ACE inhibition significantly reduced the rate of death, myocardial infarction, and stroke and reduced the intima-to-media ratio of carotid arteries in patients at high risk for cardiovascular events.It is likely that these findings will have wide-ranging implications for the treatment of cardiovascular disease, and the contrasting results with respect to ACE inhibitors and vitamin E provide an opportunity to revisit the role of oxidative stress in vascular disease.
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