Application of cyclodextrins to chiral analysis by ¹H NMR spectroscopy

Abstract

Abstract The influence of inclusion complex formation between cyclodextrins (chiefly the β‐polymer) and a variety of chiral antihistaminic and analgesic agents on the 1 H NMR features of both guest and host partners is reported. In many cases equivalent protons of antipodes give resonances which differ in chemical shift after inclusion, and the potential value of the data to chiral analysis and to elucidation of the structures of the inclusion complexes is demonstrated.