Concepedia

TAT-Bim Induces Extensive Apoptosis in Cancer Cells

Hiroyuki Kashiwagi, Jonathan E. McDunn, Peter S. Goedegebuure, Mary C. Gaffney, Katherine Chang, Kathryn Trinkaus, David Piwnica‐Worms, Richard S. Hotchkiss, William G. Hawkins

Annals of Surgical Oncology · 2007 · 65 citations · 28 references

DOI

Concepts

References

28

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Anthony Letai, Michael C. Bassik, Loren D. Walensky et al. · Cancer Cell · 2002 · 1.6K citations · Full text

, , +16

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

Kui Lei, Roger J. Davis · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

, , +16

Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

Limin Hu, Judith Hofmann, Yiling Lu et al. · PubMed · 2002 · 362 citations

, , +17

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

Mamta Chawla‐Sarkar, Songa Bae, Frederic J. Reu et al. · Cell Death and Differentiation · 2004 · 359 citations

, , +16

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy

Ting-Ting Tan, Kurt Degenhardt, Deirdre A. Nelson et al. · Cancer Cell · 2005 · 288 citations · Full text

, , +17